setuptools-rust is a setuptools helpers for Rust Python extensions. It supports PyO3 by default.

For detailed usage, please refer to its README

To build a source code distribution, you need to add the following lines to your MANIFEST.in file to ensure it correctly packages Rust extension source code.

include Cargo.toml
recursive-include src *

Then you can build a source code distribution by (assuming you have already written a setup.py):

python setup.py sdist

To build a binary wheel, manylinux would be a natural choice for Linux.

Take the example project in setuptools-rust repository for example, we have a build-wheels.sh to be used with Docker to build manylinux1 wheels. First you need to pull the manylinux1 Docker image:

$ docker pull quay.io/pypa/manylinux1_x86_64

Then use the following command to build wheels for supported Python versions:

$ docker run --rm -v `pwd`:/io quay.io/pypa/manylinux1_x86_64 /io/build-wheels.sh

You will find all the wheels in dist directory:

$ ls dist
hello_rust-1.0-cp27-cp27m-linux_x86_64.whl       hello_rust-1.0-cp35-cp35m-linux_x86_64.whl
hello_rust-1.0-cp27-cp27m-manylinux1_x86_64.whl  hello_rust-1.0-cp35-cp35m-manylinux1_x86_64.whl
hello_rust-1.0-cp27-cp27mu-linux_x86_64.whl      hello_rust-1.0-cp36-cp36m-linux_x86_64.whl
hello_rust-1.0-cp27-cp27mu-manylinux1_x86_64.whl hello_rust-1.0-cp36-cp36m-manylinux1_x86_64.whl

The *-manylinux1_x86_64.whl files are the manylinux1 wheels that you can upload to PyPI.